2010 marks the centennial of the publication of the Flexner report [1]. YJBMcommemorates this anniversary with two articles from our archives: One chronicles the expansion of Yale’s medical school in the wake of the report’s publication; the other is a personal reminiscence written by Flexner for YJBM some 50 years ago. Together, these articles invite a reconsideration of an important moment in the history of 20th century American medical education.